Published articles (2022) endorse Optics11 Life’s unique technology.
Written by Fabiany Da Costa Gonçalves and illustrated by Yashjit Gangopadhyay
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Studies on the mechanobiology of cells, spheroids, organoids, tissues, and biomaterials are developing rapidly using our Chiaro, Piuma, and Pavone Nanoindenters.
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Most studies have investigated diseases and new therapies in regenerative medicine. More than 400 publications have cited Optics11 Life Nanoindenters in leading scientific journals.
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The publication rate has increased significantly since 2015. In 2022 alone, we appeared in 82 publications.
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Check out the list of new publications from 2022 and the different applications of the Chiaro, Piuma, and Pavone Nanoindenters.
1. Cells
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No.
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Type
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Keywords
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Author
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|---|---|---|---|
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1.1
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Multi-cellular
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cell polarization, aggregates
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cellular aggregates
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1.2
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Embryo
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keratin filaments, embryonic membranes
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1.3
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Epithelial cells
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mechanoresponse, monolayers, 3D microwells
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monolayers, hexanematic crossover
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RhoA autoregulation, apical microvilli
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cortical tension, desmosomal morphogenesis
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substrate stiffness, apical-basal polarization, renal
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cell signalling, corneal
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1.4
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Hepatocytes
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extracellular matrix, iPSC-derived phenotype
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1.5
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Endothelial cells
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vascular self-assembly, 3D printing
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stiffness sensing, smooth muscle cells
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proinflammatory response, smooth muscle cells
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1.6
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Neurons
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neuronal viscoelasticity
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1.7
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Cardiomyocytes
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3D scroll wave chaos, deep neural networks
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contractile dysfunction, extracellular stiffness
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microtubules, tubulin detyrosination
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1.8
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Fibroblasts
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vaginal fibroblast, polyisocyanides, in-vitro model
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soft substrates, fibroblast reprogramming
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non-muscle myosin, durotaxis
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1.9
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Myocytes
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myocyte mechanics, atomic force microscopy
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myonuclear re-modelling
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1.10
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Cartilage
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regeneration, BMSCs
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non-surgical recontouring, auricular cartilage
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1.11
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Stem cells
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bone marrow, mesenchymal stem cells, polymer, hydrogel
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cancer cell monolayers, mesenchymal stem cells
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mechanosensitivity, aging, muscle stem cell
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Breast Cancer Awareness: How 3D Disease Models and Mechanical Biomarkers are Paving the Way
October is more than just pumpkin spice lattes and Halloween costumes. It’s also Breast Cancer Awareness Month, a time when the world comes together to
Optics11 Life Inc. Joins Cell Manufacturing Research Initiative to Further Advance Cell Therapy Discovery
Boston, MA, September 26th, 2023 Optics11 Life Inc., an innovator in the development of user-friendly, robust nanoindenters for characterizing the mechanics of cell, tissue and
Optics11 Life September 2023 Highlights
September breezed past in a whirlwind of emotions, innovations, and memorable insights. Amidst all the excitement of conferences and corporate conventions, the zeal to zoom
Exploring the Role of Mechanical Forces and the Potential of Nanoindentation for Monitoring and Accelerating the Healing Process
Wounds arise from various causes, including surgery, injury, extrinsic factors (e.g., pressure, burns, and cuts), or illnesses like diabetes and vascular diseases 1. Mechanical forces
Controlling vascular remodeling with Pavone Nanoindenter
Researchers at the University of Twente (Netherlands) have designed advanced growth factor-delivering systems to mimic angiogenesis. To provide long-term functionality to the designed vasculature, they
Hydrogel mechanics are a key driver in bioengineering
Hydrogels, a versatile class of biomaterials, play a central role in bioengineering and regenerative medicine. They are a three-dimensional (3D) network of hydrophilic polymers made
2. Tissues
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No.
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Type
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Keywords
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Author
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|---|---|---|---|
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2.1
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Cardiac tissue
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cardiac fibrosis, organ-on-chip, iPSC cardiomyocytes
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drug screening, scanning electrochemical microscpoy
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2.2
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Eyes (ocular)
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retinal ganglion cell, lamina cribrosa, extracellular matrix
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corneal epithelium, diabetic retinopathy, retinoic acid
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2.3
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Liver
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liver stiffness, single cell biomechanics, NAFLD
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2.4
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Kidney
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diabetic kidney disease, fibrosis, matrix stiffness
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2.5
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Nerve
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nerve regeneration, micropatterns, peptide gradient
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2.6
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Carotid plaque
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viscoelasticity, kelvin-voigt fractional derivative (KVFD)
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3. Others
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No.
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Type
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Keywords
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Author
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|---|---|---|---|
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3.1
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Spheroids
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mechanically tunable biomimetic hydrogel, MSCs
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3D cell cultures, hydrogels, multicellular spheroids
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tunable hydrogel, multicellular spheroids
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3.2
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Organoids
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HIC organoids, hydrogel, ECM
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MDCK cell sheet, 3D deformation, neural organoids
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3.3
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Microenvironment
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extracellular microenvironment, ECM, YAP activation
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ECM, fibroblasts, vascular ehlers-danlos syndrome
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neuroblastoma, ECM, YAP activation
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micromechanics, mechanical characterisation
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3.4
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Tumour
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Adenocarcinoma, 3D cell culture models, ECM
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tumour microenvironment, cellular spheroids, hepatic fibrosis
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breast cancer, gene expression, ECM, cell signalling
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tumor-like microcapsules
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3.5
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Contact Lens
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Delefilcon A, kalifilcon A
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